Scientific Name: PYY3-36 (Peptide Tyrosine Tyrosine)
Clinical Test Expectation: Appetite suppression. Intestinal dehydration
MG Strength: 5 mg per vial
Detailed Product Information
PYY3-36 is a hormone concerned with hunger and the lack of hunger (satiety). Soon after eating, PYY is secreted into the blood by cells lining the lower small intestine (the ileum) and the colon. The release of PYY begins before nutrients arrive in the lower small intestine and the colon. The further release of PYY is stimulated by nutrients within the lower small intestine and the colon. PYY decreases food intake by inhibiting gut motility. It acts as an “ileal brake” to cause a sense of satiety.
Peptide YY (PYY) belongs to a family of peptides that is critically involved in the regulation of appetite. It is synthesized in specialized cells (L-cells) that are found primarily in the distal gastrointestinal tract. Circulating PYY levels rise within 15 min after a meal in proportion to the amount of calories ingested and remain elevated for ∼6 h (1). The two natural forms of this peptide, PYY1–36 and PYY3–36, have opposing effects on food intake: PYY1–36 stimulates appetite, whereas PYY3–36 (the major circulating form) inhibits feeding (3–5).
PYY3–36 reduces food intake by acting on appetite regulation centers in the hypothalamus. Specifically, PYY3–36 is an agonist of the presynaptic neuropeptide Y (NPY) Y2 receptor, which inhibits NPY neuronal activity in the arcuate nucleus and thereby activates adjacent pro-opiomelanocortin (POMC) neurons. In addition to their critical role in the control of feeding, both NPY and POMC affect insulin action. Intracerebroventricular infusion of NPY induces hyperinsulinemia and insulin resistance in rats. In contrast, central administration of α-melanocyte-stimulating hormone, a splice product of the POMC peptide, enhances insulin sensitivity. In view of the fact that PYY3–36 inhibits NPY neuronal activity and activates that of POMC, we wondered whether it could improve insulin sensitivity “directly” (i.e., through a mechanism independent of food intake and body weight). To address this question, we infused PYY3–36 intravenously and quantified its acute effects on glucose and fatty acid flux during a hyperinsulinemic-euglycemic clamp in mice without access to food during the experiment.
Mixing and our recommended dosage
You inject 2ml water into the vial of PYY3-36 from the water vial. 1 full syringe is 1ml. you then wait for the vial powder content to dissolve and once dissolved and clear you draw out 0.8 (200mcg) on the syringe and inject it into the tummy under the skin into the fatty skin layer. 1 vial lasts 20 days
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