Oxytocin and its effect on Covid-19 Spike protein

A repurposed drug screen identifies compounds that inhibit the binding of the COVID-19 spike protein to ACE2

Oxytocin and its effect on Covid-19 Spike protein – Buy Oxytocin here : https://www.peptides.co.za/product/oxytocin/

Kaleb B. Tsegay, Christiana M. Adeyemi, Edward P. Gniffke, D. Noah Sather, John K. Walker, View ORCID ProfileStephen E. P. Smith doi: https://doi.org/10.1101/2021.04.08.439071 This article is a preprint and has not been certified by peer review [what does this mean?].

Abstract

Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments or prophylactics. Here, we screened 2701 compounds from a commercial library of drugs approved by international regulatory agencies for their ability to inhibit the binding of recombinant, trimeric SARS-CoV-2 spike protein to recombinant human ACE2. We identified 56 compounds that inhibited binding by <90%, measured the EC50 of binding inhibition, and computationally modeled the docking of the best inhibitors to both Spike and ACE2. These results highlight an effective screening approach to identify compounds capable of disrupting the Spike-ACE2 interaction as well as identifying several potential inhibitors that could serve as templates for future drug discovery efforts.

Competing Interest Statement

SCRI has submitted a provisional patent on the assay and compounds described in this manuscript.

Paper in collection COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

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